In the 1700s, a teaching assistant at a medical university in Vienna was very much disliked by his students. So much so that the students ambushed the TA, blindfolded him, and told him he was about to be decapitated. They bowed his head onto the chopping block, and then dropped a wet cloth onto the back of his neck. Convinced it was the kiss of a steel blade, the assistant died on the spot.
While the data is a bit sparse on the veracity of this claim, modern research is exploring much more intently the mind’s ability to both heal and harm. The placebo effect comes from the Latin “I will please”, and every clinical trial randomly assigns a cohort of patients to a placebo in the form of an inert pill.
Much of the research shows that belief can often lead to improved outcomes. By believing this pill will help, many patients show an actual physiologic response.
But there’s a curious corollary to the placebo effect. Many of these patients also report puzzling side effects such as nausea, headaches, or pain – symptoms that are highly unlikely to come from an inert tablet. What’s causing this phenomenon is that all patients are given the exact same health warnings regarding the medication – whether they are taking the real drug or the placebo. And yet, the expectation of symptoms produces physical manifestations in many placebo takers.
It’s called the nocebo effect.
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